Neuroradiology · 2025
Significance of the corpus callosum and inferior fronto-occipital fasciculus in recovery after traumatic brain injury.
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Pogosbekian E L, Sharova E V, Fadeeva L M, Alexandrova E V, Chekhonin I V, Zakharova N E, Pronin I N
Аннотация
OBJECTIVE: To analyze the correlations between the consciousness state scores and the fractional anisotropy (FA) values in various segments of the Corpus Callosum (CC) and Inferior Fronto-Occipital Fasciculus (IFOF) at different stages of recovery after traumatic brain injury (TBI).
METHODS: Diffusion tensor imaging (DTI) was performed in 43 TBI patients and 22 healthy volunteers. The consciousness levels were estimated with the CRS-R scale. The tracts were divided into segments using a template based on tractograms of healthy volunteers, and the correlations between the CRS-R scores and the FA values were calculated for each tract segment.
RESULTS: In the acute period after TBI, 15 segments of the CC and IFOF demonstrated significant correlations (p < 0.05). In the long-term period, the highest number (24) of correlations were found in the studied tracts segments. In the subacute period, only 3 segments with correlations were detected.
CONCLUSIONS: We propose a new pipeline, which yields spatial localization of correlations between the fractional anisotropy values and the CRS-R scores in patients after TBI. It allows us to make assumptions about the functioning of neural networks.
SIGNIFICANCE: This work provides new information concerning the organization of fiber tracts and neural networks in TBI patients and may improve neurorehabilitation approaches.
METHODS: Diffusion tensor imaging (DTI) was performed in 43 TBI patients and 22 healthy volunteers. The consciousness levels were estimated with the CRS-R scale. The tracts were divided into segments using a template based on tractograms of healthy volunteers, and the correlations between the CRS-R scores and the FA values were calculated for each tract segment.
RESULTS: In the acute period after TBI, 15 segments of the CC and IFOF demonstrated significant correlations (p < 0.05). In the long-term period, the highest number (24) of correlations were found in the studied tracts segments. In the subacute period, only 3 segments with correlations were detected.
CONCLUSIONS: We propose a new pipeline, which yields spatial localization of correlations between the fractional anisotropy values and the CRS-R scores in patients after TBI. It allows us to make assumptions about the functioning of neural networks.
SIGNIFICANCE: This work provides new information concerning the organization of fiber tracts and neural networks in TBI patients and may improve neurorehabilitation approaches.