Zhonghua fu chan ke za zhi · 1996
[Study on cellular proliferation activity of placental site trophoblastic tumor].
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Xie X, Shi Y, Zhao C
Аннотация
OBJECTIVE: To study the relationship among the cellular proliferation activity, benign clinical process and pathologic characteristics of placental site trophoblastic tumor (PSTT).
METHODS: Paraffin-embedded blocks from ten patients with PSTT were reexamined by mitotic count, argyrophilic nucleolar organizer regions (AgNOR) staining and flow cytometric DNA analysis. Five cases of hydatidiform mole (HM) and 5 choriocarcinoma (CC) were chosen as controls.
RESULTS: Mean mitotic figures of PSTT were 1.3 (0-3) per 10 high power field, while those of HM and CC were 0.8 (0-2) and 2.2 (1-4) respectively. AgNOR number of PSTT was 2.70 +/- 0.55 per cell, while those of HM and CC were 1.96 +/- 0.38 and 4.50 +/- 0.73 respectively. Flow cytometric DNA content revealed that PSTT had DNA index (DI) of 1.10, S phase of 16.7% and proliferating index (PI) of 26.6%. Eight of 10 Cases were followed up, 7 are alive and 1 died of primary lung cancer.
CONCLUSION: PSTT has relative low cellular proliferation activity. The good clinical procedure and benign pathological feature of PSTT may be associated with its diploidy DNA and low cellular proliferation activity.
METHODS: Paraffin-embedded blocks from ten patients with PSTT were reexamined by mitotic count, argyrophilic nucleolar organizer regions (AgNOR) staining and flow cytometric DNA analysis. Five cases of hydatidiform mole (HM) and 5 choriocarcinoma (CC) were chosen as controls.
RESULTS: Mean mitotic figures of PSTT were 1.3 (0-3) per 10 high power field, while those of HM and CC were 0.8 (0-2) and 2.2 (1-4) respectively. AgNOR number of PSTT was 2.70 +/- 0.55 per cell, while those of HM and CC were 1.96 +/- 0.38 and 4.50 +/- 0.73 respectively. Flow cytometric DNA content revealed that PSTT had DNA index (DI) of 1.10, S phase of 16.7% and proliferating index (PI) of 26.6%. Eight of 10 Cases were followed up, 7 are alive and 1 died of primary lung cancer.
CONCLUSION: PSTT has relative low cellular proliferation activity. The good clinical procedure and benign pathological feature of PSTT may be associated with its diploidy DNA and low cellular proliferation activity.