[Analysis of a consecutive series of 421 cases of genital condylomata. Course, management and therapeutic results].

The evolution of 421 cases of condylomata that have been followed seems to be less favourable than in other series in the literature. 45% of these cases became worse and 13% regressed, especially in the first year after diagnosis. Sometimes the case progresses in an atypical manner. It can be extremely rapid so that it becomes intra-epithelial carcinoma in less than a year in young patients who have not been pregnant or not had babies and who have cervical and vaginal infections and who use combined oral contraceptive pills. On the other hand it can "seesaw" with periods of worsening alternating with periods of regression. Treatment should be with local destruction using the CO2 laser if the lesion is on the exocervix or laser CO2 conisation if it is an endocervical lesion. It is important to distinguish when treatments have been incomplete. This involves some persistence of the lesion even after treatment, or recurrences which can be less or more serious than the initial lesion. 11% of the cases treated by local destruction showed that some of the lesion persisted after the treatment and that there were 13% of recurrences. After conisation on the other hand 8% of cases were shown to be incompletely treated and 3% showed recurrences.