A new verrucosane diterpenoid from the Vietnamese liverwort Plagiochila bantamensis.

A new verrucosane-type diterpenoid, bantamenside (1), along with six known compounds (2-7), was isolated from the Vietnamese liverwort Plagiochila bantamensis. The structure of the new compound was determined using comprehensive spectroscopic methods, including 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Furthermore, all isolated compounds were evaluated for their ability to inhibit nitric oxide (NO) production. Compounds 1-3 and 6-7 demonstrated notable NO inhibitory activity, with IC50 values ranging from 12.85 to 51.37 µM, outperforming or comparable to that of the positive control L-NMMA (IC50 41.30 ± 6.60 µM).