Malignant potential of perianal condyloma acuminatum.

Perianal condyloma is usually a benign disease, but may become locally aggressive; carcinomatous change may occur. This disease could be potentially malignant, and if malignant transformation occurs the treatment should include abdominoperineal resection. Perianal condylomas in association with anal fistula show malignant behavior; should such malignant behavior develop in perianal condyloma, the disease should be treated aggressively with excision and immunotherapy. Abdominoperineal resection may be necessary.