Frontiers in medicine · 2026
Impact of different anesthetics on ischemia reperfusion injuries in patients undergoing hepatectomy: a network meta-analysis.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Shaojuan, Tian Fangyuan, Zhang Rui, Deng Zehui, Zhou Ling, Ren Lin, Wu Fengbo
Аннотация
BACKGROUND: Hepatectomy, a commonly employed surgical approach for treating liver-related disorders, has emerged as the primary method for the radical treatment of early stage liver cancer. This network meta-analysis was conducted to evaluate the impacts of different anesthetics on ischemia reperfusion injuries in patients undergoing hepatectomy.
METHODS: Randomized controlled trials (RCTs) and cohort studies were identified through searches in four databases, PubMed, Embase, the Cochrane Library, and the Web of Science, up to February 12, 2025. Non-English studies were excluded, and this study was conducted in compliance with PRISMA-NMA guidelines. Bayesian network meta-analysis was employed based on the R 4.3.2 and Stata 15.1. The efficacy of each intervention was evaluated through SUCRA (surface under the cumulative ranking curve).
RESULTS: The analysis included 19 studies with a total of 1,319 participants. In terms of reducing aspartate transaminase (AST) levels, the combination of propofol and sevoflurane exhibited the highest effectiveness (SUCRAs: 71.82%), followed by the combination of propofol, isoflurane, and fentanyl (SUCRAs: 61.87%), and sevoflurane monotherapy (SUCRAs: 58.61%). The combination of propofol and sevoflurane (SUCRAs: 71.94%) ranked first for reducing ALT levels, followed by propofol monotherapy (SUCRAs: 61.71%) and the combination of propofol and sufentanil (SUCRAs: 58.59%).
CONCLUSION: The combination of propofol and sevoflurane appear to be the most effective approach for reducing AST and ALT levels. This combination could serve as a favorable anesthetic strategy to limit hepatic enzyme elevations after hepatectomy, thus supporting liver function protection.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/home, identifier CRD42023472070.
METHODS: Randomized controlled trials (RCTs) and cohort studies were identified through searches in four databases, PubMed, Embase, the Cochrane Library, and the Web of Science, up to February 12, 2025. Non-English studies were excluded, and this study was conducted in compliance with PRISMA-NMA guidelines. Bayesian network meta-analysis was employed based on the R 4.3.2 and Stata 15.1. The efficacy of each intervention was evaluated through SUCRA (surface under the cumulative ranking curve).
RESULTS: The analysis included 19 studies with a total of 1,319 participants. In terms of reducing aspartate transaminase (AST) levels, the combination of propofol and sevoflurane exhibited the highest effectiveness (SUCRAs: 71.82%), followed by the combination of propofol, isoflurane, and fentanyl (SUCRAs: 61.87%), and sevoflurane monotherapy (SUCRAs: 58.61%). The combination of propofol and sevoflurane (SUCRAs: 71.94%) ranked first for reducing ALT levels, followed by propofol monotherapy (SUCRAs: 61.71%) and the combination of propofol and sufentanil (SUCRAs: 58.59%).
CONCLUSION: The combination of propofol and sevoflurane appear to be the most effective approach for reducing AST and ALT levels. This combination could serve as a favorable anesthetic strategy to limit hepatic enzyme elevations after hepatectomy, thus supporting liver function protection.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/home, identifier CRD42023472070.