Nuclear inclusions of tonofilaments and keratohyalin granules in the condyloma acuminatum.

Electron-microscopic investigations of the condyloma acuminatum show different nuclear inclusions in keratinocytes of the granular layer or the layer immediately below. Fibrous structures were indentified as tonofilaments and irregularly shaped electron-dense substances as keratohyalin. However the question remains as to whether there is a connection between the viral infection and the occurrence of such intranuclear inclusions.