Topical treatment of penile condylomata acuminata with colchicine at 48-72 hours intervals.

We previously demonstrated that 8% solutions of colchicine in ethanol eradicated penile warts in 36% of patients after a single application and in an additional 12% after a second application performed at least a week after the first. In the present study only 30% of 115 men were cured when penile warts were painted twice at intervals of 48 hours with 2% solutions and 72 hours with 4% and 8% solutions of colchicine. The lack of additive therapeutic effect accruing from the second application and the high frequency of intolerable side effects when using the latter treatment program indicate that this regimen is unsuitable for condylomata therapy.