The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2011
Creatinaemia at birth is equal to maternal creatinaemia at delivery: does this paradigm still hold?
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Kuppens Maike, George Isabelle, Lewi Liesbeth, Levtchenko Elena, Allegaert Karel
Аннотация
OBJECTIVE: The paradigm that creatinaemia at birth is equal to maternal creatinaemia may also depend upon the quantification technique applied. Paired maternal-neonatal creatinaemia samples in whom Jaffe in both or compensated Jaffe (maternal) and enzymatic quantification (neonate) were applied.
METHODS: Extreme low birth weight infants in two time intervals were included when paired maternal-neonatal creatinaemia samples were available. In cohort 1 (2000-2005), creatinaemia (mothers and neonates) was based on Jaffe assay. In cohort 2 (2007-2010), maternal creatinaemia was based on compensated Jaffe. In neonates, an enzymatic technique was applied. Unpaired Mann Whitney U, paired Wilcoxon and Bland-Altman were used.
RESULTS: Based on 80 and 52 paired creatinaemia samples, there was no significant difference between maternal (0.80, 0.41-1.6 mg.dl(-1)) and neonatal creatinaemia (0.78, 0.31-1.46 mg.dl(-1)) in cohort 1 while a significant difference (p < 0.001) between maternal (0.6, 0.29-2.24 mg.dl(-1)) and neonatal creatinaemia (0.67, 0.4-2.2 mg.dl(-1)) was observed for cohort 2. Using Bland-Altman, the fit was perfect for cohort 1 (mean diff -0.02 mg.dl(-1)), but not for cohort 2 (-0.08 mg.dl(-1)).
CONCLUSIONS: The quantification method affects the paradigm that creatinaemia at birth is similar to maternal creatinaemia. Maternal and neonatal creatinaemia values depend on the method used. Consequently, method-specific reference values are needed.
METHODS: Extreme low birth weight infants in two time intervals were included when paired maternal-neonatal creatinaemia samples were available. In cohort 1 (2000-2005), creatinaemia (mothers and neonates) was based on Jaffe assay. In cohort 2 (2007-2010), maternal creatinaemia was based on compensated Jaffe. In neonates, an enzymatic technique was applied. Unpaired Mann Whitney U, paired Wilcoxon and Bland-Altman were used.
RESULTS: Based on 80 and 52 paired creatinaemia samples, there was no significant difference between maternal (0.80, 0.41-1.6 mg.dl(-1)) and neonatal creatinaemia (0.78, 0.31-1.46 mg.dl(-1)) in cohort 1 while a significant difference (p < 0.001) between maternal (0.6, 0.29-2.24 mg.dl(-1)) and neonatal creatinaemia (0.67, 0.4-2.2 mg.dl(-1)) was observed for cohort 2. Using Bland-Altman, the fit was perfect for cohort 1 (mean diff -0.02 mg.dl(-1)), but not for cohort 2 (-0.08 mg.dl(-1)).
CONCLUSIONS: The quantification method affects the paradigm that creatinaemia at birth is similar to maternal creatinaemia. Maternal and neonatal creatinaemia values depend on the method used. Consequently, method-specific reference values are needed.