Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2012
[Progress and extensive meaning of mammalian target of rapamycin involved in restoration of nervous system injury].
СтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод в очереди
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Chen Hongju, Tang Binzhi, Qu Yi, Mu Dezhi
Аннотация
OBJECTIVE: To review the possible mechanisms of the mammalian target of rapamycin (mTOR) in the neuronal restoration process after nervous system injury.
METHODS: The related literature on mTOR in the restoration of nervous system injury was extensively reviewed and comprehensively analyzed.
RESULTS: mTOR can integrate signals from extracellular stress and then plays a critical role in the regulation of various cell biological processes, thus contributes to the restoration of nervous system injury.
CONCLUSION: Regulating the activity of mTOR signaling pathway in different aspects can contribute to the restoration of nervous system injury via different mechanisms, especially in the stress-induced brain injury. mTOR may be a potential target for neuronal restoration mechanism after nervous system injury.
METHODS: The related literature on mTOR in the restoration of nervous system injury was extensively reviewed and comprehensively analyzed.
RESULTS: mTOR can integrate signals from extracellular stress and then plays a critical role in the regulation of various cell biological processes, thus contributes to the restoration of nervous system injury.
CONCLUSION: Regulating the activity of mTOR signaling pathway in different aspects can contribute to the restoration of nervous system injury via different mechanisms, especially in the stress-induced brain injury. mTOR may be a potential target for neuronal restoration mechanism after nervous system injury.