Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis.

OBJECTIVE

To evaluate the efficacy of superovulation and IUI versus no treatment for infertility associated with minimal or mild endometriosis.

DESIGN

Randomized trial.

SETTING(S): London Health Sciences Centre, University Campus, The University of Western Ontario, London, Ontario; and Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.

PATIENT(S): Three hundred eleven cycles in 103 couples in whom minimal or mild endometriosis was the sole identified subfertility factor.

INTERVENTION(S): Superovulation with FSH and IUI.

MAIN OUTCOME MEASURE(S): Live birth.

RESULT(S): Live birth followed 14 of 127 (11%) superovulation and IUI cycles and 4 of 184 (2%) no-treatment cycles. The odds ratio was 5.6 (95% confidence interval 1.8 to 17.4) in favor of superovulation and IUI.

CONCLUSION(S): Treatment with superovulation and IUI was associated with superior outcome both by crude live-birth rates and proportional hazard analysis.