Palladium-Catalyzed Carbonylative Sonogashira Transformations: Advancements and Insights.

Palladium-catalyzed carbonylative reactions, used as a tool for the insertion of carbonyl group into organic moieties, is a synthetically useful transformation. Carbonylative Sonogashira coupling is a convenient approach for the synthesis of α,β-acetylenic ketones which are important class of molecules in pharmaceutical and industrial fields. Development of greener approaches and environmentally benign catalytic systems put forward enormous opportunities in this field and moreover, these researches indicate the formation of heterocycles via this carbonylation strategy, which is a major highlight. Herein, we discuss the progress achieved in palladium-catalyzed carbonylative Sonogashira coupling from 2013 to 2024 and its future prospects.