Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
Exacerbation of myasthenia gravis after amoxicillin therapy: a case series.
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Vacchiano Veria, Solli Piergiorgio, Bartolomei Ilaria, Lai Giulia, Liguori Rocco, Salvi Fabrizio
Аннотация
INTRODUCTION: Myasthenia gravis (MG) can be aggravated by several classes of drugs, including antibiotics. Penicillins are considered safe drugs for the management of infectious disease in patients with MG. However, a few cases of MG exacerbations after penicillin treatment have been reported in literature.
CASE REPORTS: We report six patients with MG developing acute worsening of symptoms after amoxicillin or amoxicillin/clavulanate treatment. In most of the cases, symptoms started in a few days after antibiotic administration. In all cases, we observed a worsening of the Myasthenia Gravis Foundation of America (MGFA) clinical classification. Most patients required a therapeutic intervention with dosage increase of the previous therapy or the introduction of new drugs for MG. All patients had a full recovery to baseline neurological conditions within 1-2 months.
CONCLUSIONS: We concluded that patients receiving amoxicillin should be closely monitored for possible acute relapse.
CASE REPORTS: We report six patients with MG developing acute worsening of symptoms after amoxicillin or amoxicillin/clavulanate treatment. In most of the cases, symptoms started in a few days after antibiotic administration. In all cases, we observed a worsening of the Myasthenia Gravis Foundation of America (MGFA) clinical classification. Most patients required a therapeutic intervention with dosage increase of the previous therapy or the introduction of new drugs for MG. All patients had a full recovery to baseline neurological conditions within 1-2 months.
CONCLUSIONS: We concluded that patients receiving amoxicillin should be closely monitored for possible acute relapse.