[Insulin resistance and metabolic profile in lean and overweight/obese polycystic ovary syndrome patients].

OBJECTIVE

To evaluate insulin sensitivity and the metabolic features in normal weight and overweight/obese patients with PCOS.

SUBJECTS AND

METHODS

Forty-nine (49) patients from 18 to 45 years were retrospectively evaluated and divided into 2 groups, according to the body mass index (BMI): group 1 (18.5-24.9 kg/m(2)) and group 2 (25-40 kg/m(2)). Collected data: systolic and diastolic blood pressure; fasting and after OGTT glucose, insulin and glucose/insulin ratio; area under the curve for glucose and insulin; HOMA-IR and HOMA-beta; lipidic profile; free (FT) and total testosterone (T) levels.

RESULTS

Greater averages of pressoric levels, insulin resistance (IR) indices, triglycerides and the FT levels, in addition to lower HDL levels, were found in group 2. Neither correlation between the IMC with none of data nor of the FT and IR indices with the lipid profile were found.

CONCLUSIONS

Obesity is associated with insulin resistance and diabetes mellitus in PCOS, independently on familiar history of DM. The absence of correlation between the IR indices and the FT with the lipidic profile suggests that other factors, such as the free fatty acids, can be involved in the pathogenesis of dyslipidemia in PCOS.