Phytochemistry · 2026
Magneolign O-S: Five neolignans isolated from Magnolia officinalis Rehd. et Wils with their hepatoprotective activities.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sun Jingying, Zhang Lingzhi, Li Chuangjun, Zang Yingda, Sun Hua, Ma Jie, Zhang Dongming
Аннотация
Five undescribed neolignans (1-5), and three known compounds (6-8) were isolated from the root bark of Magnolia officinalis Rehd. et Wils. Compounds 3 and 4 were obtained as racemates and separated completely using a chiral column. Their structures were elucidated through extensive analyses of 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. The hepatoprotective activities of all isolates were assessed. Results indicated that compounds 1 and 8 exhibited significant hepatoprotective activity in both APAP- and H2O2-induced liver injury models. Further in vitro experiments demonstrated that compound 1 attenuated apoptosis by reducing reactive oxygen species production and modulating the expression of key apoptotic proteins.