Cytokines and neurodevelopmental outcomes in extremely low birth weight infants.
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Carlo Waldemar A, McDonald Scott A, Tyson Jon E, Stoll Barbara J, Ehrenkranz Richard A, Shankaran Seetha, Goldberg Ronald N, Das Abhik, Schendel Diana, Thorsen Poul, Skogstrand Kristin, Hougaard David M, Oh William, Laptook Abbot R, Duara Shahnaz, Fanaroff Avroy A, Donovan Edward F, Korones Sheldon B, Stevenson David K, Papile Lu-Ann, Finer Neil N, O'Shea T Michael, Poindexter Brenda B, Wright Linda L, Ambalavanan Namasivayam, Higgins Rosemary D, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Аннотация
STUDY DESIGN: Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants.
RESULTS: IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP.
CONCLUSIONS: CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.