A leap forward in vaccination - a molecular process of epigenetic silencing to the virus.

Immunization is a procedure that trains and strengthens host immunity against harmful foreign agents from damaging and even taking the life of the host. Immunization or vaccination has opened the era of modern medicine, contributed to independence, health, and prosperity of the nation. Resonating with current USA scientific progress, vaccinology needs to take an appropriate leap forward. The review traces the history of vaccine development in USA, recaps multidiscipline-nary research more than four-decade on acquired immunodeficiency syndrome (AIDS), appeals to generating a next-generation vaccine - chromatin vaccine and elicits the newly defined host immunity - epigenetic immunity for a cure.