Cancer biology & therapy · 2010
Bone-specific growth inhibition of prostate cancer metastasis by atrasentan.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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de Klerk Marry, Kal-van Gestel Judith A, Roelen Dave, Betjes Michiel G H, de Weerd Annelies E, Reinders Marlies E J, van de Wetering Jacqueline, Kho Marcia M L, Glorie Kristiaan, Roodnat Joke I
Аннотация
OBJECTIVE: To conduct monitoring analysis of lesion degree and long-term prognosis using ambulatory electroencephalography (aEEG) in newborns with hypoxic-ischemic encephalopathy (HIE).
PATIENTS AND METHODS: 48 cases of newborns with HIE (aged 37 to 41 weeks) as the observation group and another 50 cases of full-term infants with non-traumatic brain illness as the control group were chosen from March 2012 to March 2013. The aEEG were observed, and the continuity and sleep-wake cycle (SWC) between the two groups were compared. The relevance of aEEG monitoring results and HIE, as well as the long-term prognosis, were analyzed.
RESULTS: 33.33% (16/48) of EEG results appeared to be continuous and 20.83% (10/48) of the SWC results were mature for observation group. These EEG and SWC results are conspicuously lower than the control group 100% (50/50) and differences were statistically significant (p<0.05). The maximum voltage of observation group was 56.54±19.33 LV, notably higher than the control group (37.77±2.79 LV). The minimum voltage of the observation group was 4.26±1.25 LV, markedly lower than the control group (7.75±0.67 LV) and these differences were statistically significant (p<0.05). Correlational analysis based on the Spearman approach showed that the monitoring results are positively correlated with clinical classification of HIE. After six months of follow-up, 11 of the 48 cases (22.92%) were found to be disabled (including mental retardation and cerebral palsy).
CONCLUSIONS: aEEG enjoys easy operation, effective diagnosis, supports continuous monitoring and reflects the lesion degree as well as long-term prognosis of newborns with HIE and is, thus, highly recommended in clinical practices.
PATIENTS AND METHODS: 48 cases of newborns with HIE (aged 37 to 41 weeks) as the observation group and another 50 cases of full-term infants with non-traumatic brain illness as the control group were chosen from March 2012 to March 2013. The aEEG were observed, and the continuity and sleep-wake cycle (SWC) between the two groups were compared. The relevance of aEEG monitoring results and HIE, as well as the long-term prognosis, were analyzed.
RESULTS: 33.33% (16/48) of EEG results appeared to be continuous and 20.83% (10/48) of the SWC results were mature for observation group. These EEG and SWC results are conspicuously lower than the control group 100% (50/50) and differences were statistically significant (p<0.05). The maximum voltage of observation group was 56.54±19.33 LV, notably higher than the control group (37.77±2.79 LV). The minimum voltage of the observation group was 4.26±1.25 LV, markedly lower than the control group (7.75±0.67 LV) and these differences were statistically significant (p<0.05). Correlational analysis based on the Spearman approach showed that the monitoring results are positively correlated with clinical classification of HIE. After six months of follow-up, 11 of the 48 cases (22.92%) were found to be disabled (including mental retardation and cerebral palsy).
CONCLUSIONS: aEEG enjoys easy operation, effective diagnosis, supports continuous monitoring and reflects the lesion degree as well as long-term prognosis of newborns with HIE and is, thus, highly recommended in clinical practices.