Indian journal of pharmacology · 2021
Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation.
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Junutula Srinivas Pramod, Dubasi Sai Kiran, Reddy Padide Sai Geethika, Miryala Gireesh Kumar, Koppolu Manasa Soumya, Bandaru Sheshagiri Sharvana Bhava, Eggadi Venkateshwarlu
Аннотация
AIM: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically.
SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-performance liquid chromatography and brief psychiatry rating scale was used to determine disease progression.
RESULTS: Samples provided 61 patients, 40 were under sub-therapeutic range, 18 were under therapeutic range and 3 were above the therapeutic range.
CONCLUSION: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals for optimizing the dose of an individual patient along with the correlation of serum concentration with the clinical assessment scales.
SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-performance liquid chromatography and brief psychiatry rating scale was used to determine disease progression.
RESULTS: Samples provided 61 patients, 40 were under sub-therapeutic range, 18 were under therapeutic range and 3 were above the therapeutic range.
CONCLUSION: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals for optimizing the dose of an individual patient along with the correlation of serum concentration with the clinical assessment scales.