Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica · 2026
Prospective observational comparative study on antibiotic prophylaxis in cystoscopy: towards a rational use of antimicrobials.
СтатьяНаблюдательное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Magno Serrano Pedro, Barros Pedro, Dores Marco, Coutinho Aníbal
Аннотация
INTRODUCTION: Antibiotic resistance represents a major public health problem driven by inappropriate antimicrobial use. Cystoscopy is a common urological procedure associated with a low risk of urinary tract infection (UTI), and the role of routine antibiotic prophylaxis remains controversial.
OBJECTIVE: To evaluate the effectiveness of antibiotic prophylaxis in preventing post-cystoscopy UTI.
MATERIALS AND METHODS: A prospective observational comparative study including 297 patients undergoing outpatient cystoscopy. Patients were assigned to Group A (no prophylaxis, n=161) and Group B (cefuroxime 500 mg prophylaxis, n=136). Urine cultures were obtained one hour before and one week after cystoscopy. Significant bacteriuria was defined as >104 CFU/ml. Risk factors were analyzed according to current literature. Fisher's exact test and multivariate logistic regression were performed. Statistical analysis was performed using SPSS/R.
RESULTS: UTI occurred in 5.59% of patients without prophylaxis and 5.88% with prophylaxis (p=1.00). Antibiotic prophylaxis did not reduce infection risk (OR 0.95; 95% CI 0.36-2.53). Baseline characteristics and risk factors were similar between groups. No independent predictor reached statistical significance.
CONCLUSIONS: Routine antibiotic prophylaxis does not reduce post-cystoscopy UTI incidence in low-risk patients, supporting restrictive and rational antimicrobial use.
OBJECTIVE: To evaluate the effectiveness of antibiotic prophylaxis in preventing post-cystoscopy UTI.
MATERIALS AND METHODS: A prospective observational comparative study including 297 patients undergoing outpatient cystoscopy. Patients were assigned to Group A (no prophylaxis, n=161) and Group B (cefuroxime 500 mg prophylaxis, n=136). Urine cultures were obtained one hour before and one week after cystoscopy. Significant bacteriuria was defined as >104 CFU/ml. Risk factors were analyzed according to current literature. Fisher's exact test and multivariate logistic regression were performed. Statistical analysis was performed using SPSS/R.
RESULTS: UTI occurred in 5.59% of patients without prophylaxis and 5.88% with prophylaxis (p=1.00). Antibiotic prophylaxis did not reduce infection risk (OR 0.95; 95% CI 0.36-2.53). Baseline characteristics and risk factors were similar between groups. No independent predictor reached statistical significance.
CONCLUSIONS: Routine antibiotic prophylaxis does not reduce post-cystoscopy UTI incidence in low-risk patients, supporting restrictive and rational antimicrobial use.