Nanomedicine (London, England) · 2017
Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease.
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Lin Yuh-Feng, Lee Yu-Hsuan, Hsu Yung-Ho, Chen Yi-Jie, Lin Yuan-Feng, Cheng Fong-Yu, Chiu Hui-Wen
Аннотация
AIM: We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD).
MATERIALS & METHODS: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy.
RESULTS: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD.
CONCLUSION: Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.
MATERIALS & METHODS: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy.
RESULTS: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD.
CONCLUSION: Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.
Предметные рубрики MeSH
AnimalsAntibodiesAutophagyCell LineCell SurvivalCreatinineDrug CarriersDrug LiberationEpithelial CellsHepatitis A Virus Cellular Receptor 1HumansInflammasomesInterleukin-1betaKidney TubulesLactic AcidMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinNanoparticlesNephritis, InterstitialPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRenal Insufficiency, ChronicResveratrolStilbenes