Current pain and headache reports · 2021
Recent Advances in the Treatment of Opioid Use Disorder.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kuppalli Sumanth, Seth Raghav, Orhurhu Vwaire, Urits Ivan, Kaye Alan D, Hunter Corey, Gulati Amitabh, Adekoya Peju, Kaye Adam M, Jones Mark R
Аннотация
PURPOSE OF REVIEW: Opioid use disorder (OUD) remains a national epidemic with an immense consequence to the United States' healthcare system. Current therapeutic options are limited by adverse effects and limited efficacy.
RECENT FINDINGS: Recent advances in therapeutic options for OUD have shown promise in the fight against this ongoing health crisis. Modifications to approved medication-assisted treatment (MAT) include office-based methadone maintenance, implantable and monthly injectable buprenorphine, and an extended-release injectable naltrexone. Therapies under investigation include various strategies such as heroin vaccines, gene-targeted therapy, and biased agonism at the G protein-coupled receptor (GPCR), but several pharmacologic, clinical, and practical barriers limit these treatments' market viability. This manuscript provides a comprehensive review of the current literature regarding recent innovations in OUD treatment.
RECENT FINDINGS: Recent advances in therapeutic options for OUD have shown promise in the fight against this ongoing health crisis. Modifications to approved medication-assisted treatment (MAT) include office-based methadone maintenance, implantable and monthly injectable buprenorphine, and an extended-release injectable naltrexone. Therapies under investigation include various strategies such as heroin vaccines, gene-targeted therapy, and biased agonism at the G protein-coupled receptor (GPCR), but several pharmacologic, clinical, and practical barriers limit these treatments' market viability. This manuscript provides a comprehensive review of the current literature regarding recent innovations in OUD treatment.
Предметные рубрики MeSH
Analgesics, OpioidBuprenorphineDelayed-Action PreparationsDrug ImplantsHumansInjections, IntramuscularMethadoneMolecular Targeted TherapyNaltrexoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersReceptors, G-Protein-CoupledReceptors, Opioid, muSecologanin Tryptamine AlkaloidsThiophenesUreaVaccines