Journal of clinical laboratory analysis · 2025
Iron Profile Variability in Hemodialysis Chronic Kidney Disease Patients.
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Ogolla Collince Odiwuor, Karani Lucy W, Musyoki Stanslaus, Maruti Phidelis
Аннотация
BACKGROUND: Chronic kidney disease (CKD) constitutes one of the most important global health challenges and iron deficiency (ID) anemia is a frequent complication, especially in patients on dialysis.
OBJECTIVES: This study aimed to assess differences in iron profile in dialysis-adherent and non-adherent chronic kidney disease subjects and analyze the profiles between both groups.
METHODS: One hundred and twenty patients undergoing hemodialysis were included in this cross-sectional study, classified into two subcategories of dialysis adherence. The parameters of iron profile-also defined as serum ferritin, transferrin saturation (TSAT), hemoglobin, and serum iron-were studied. Multivariate regression analysis was carried out, adjusting for possible confounders such as age, sex, diabetes, and duration of dialysis.
RESULTS: Serum ferritin was significantly higher among adherent patients (235.6 ± 120.2 ng/mL vs. 185.2 ± 105.3 ng/mL; p = 0.03), as were TSAT (33.4% ± 9.3% vs. 28.8% ± 10.2%; p = 0.02) and hemoglobin (11.5 ± 1.8 g/dL vs. 10.2 ± 2.1 g/dL; p = 0.04). Non-adherence to the therapy was associated with a significantly higher number of patients having iron deficiency anemia (63% in non-adherent vs. 40% in adherent patients; p = 0.01). Multivariate analysis confirmed that dialysis adherence was independently associated with better iron status (p < 0.05 for all parameters).
CONCLUSION: In hemodialysis patients, adherence to dialysis presents as a strong predictor of a better iron profile. Strategies that improve adherence to dialysis treatment by optimizing iron metabolism among chronic kidney disease patients should be in place.
OBJECTIVES: This study aimed to assess differences in iron profile in dialysis-adherent and non-adherent chronic kidney disease subjects and analyze the profiles between both groups.
METHODS: One hundred and twenty patients undergoing hemodialysis were included in this cross-sectional study, classified into two subcategories of dialysis adherence. The parameters of iron profile-also defined as serum ferritin, transferrin saturation (TSAT), hemoglobin, and serum iron-were studied. Multivariate regression analysis was carried out, adjusting for possible confounders such as age, sex, diabetes, and duration of dialysis.
RESULTS: Serum ferritin was significantly higher among adherent patients (235.6 ± 120.2 ng/mL vs. 185.2 ± 105.3 ng/mL; p = 0.03), as were TSAT (33.4% ± 9.3% vs. 28.8% ± 10.2%; p = 0.02) and hemoglobin (11.5 ± 1.8 g/dL vs. 10.2 ± 2.1 g/dL; p = 0.04). Non-adherence to the therapy was associated with a significantly higher number of patients having iron deficiency anemia (63% in non-adherent vs. 40% in adherent patients; p = 0.01). Multivariate analysis confirmed that dialysis adherence was independently associated with better iron status (p < 0.05 for all parameters).
CONCLUSION: In hemodialysis patients, adherence to dialysis presents as a strong predictor of a better iron profile. Strategies that improve adherence to dialysis treatment by optimizing iron metabolism among chronic kidney disease patients should be in place.