Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology · 2016
[ROLE OF TGFβ-INDUCTION AND GASTROINTESTINAL MYOFIBROBLASTS IN PATHOMORPHOGENESIS OF CHRONIC GASTRITIS IN PATIENTS WITH MARFAN SYNDROME AND MARFAN-LIKE STATES].
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Rudoy A S, Letkovskaya T A, Uryvaev A M, Reutsky I P
Аннотация
AIM: The aim was to explore the features of epithelial morphogenesis and reparation of gastric mucosa in chronic gastritis in patients with Marfan syndrome and Marfan -like states.
MATERIALS AND METHODS: A histological evaluation and immunohistochemical analysis of the expression of antibodies against α-actin smooth muscle (α-SMA), collagen type III and transforming growth factor β (TGFβ) in the gastric mucosa in 50 patients with hereditary disorders of connective tissue between the ages of 17 to 41 years were performed.
RESULTS: In patients with Marfan syndrome and marfan-like states chronic gastritis was an unfavorable factor for the progression of the background atrophic and fibrotic processes in the gastric mucosa. It proved a key role disinhibited to TGFβ activity-dependent activation of fibrogenesis of subepithelial myofibroblasts (α-SMA +) with the development of a special morphogenetic variants of early chronic atrophic multifocal gastritis at a young age.
MATERIALS AND METHODS: A histological evaluation and immunohistochemical analysis of the expression of antibodies against α-actin smooth muscle (α-SMA), collagen type III and transforming growth factor β (TGFβ) in the gastric mucosa in 50 patients with hereditary disorders of connective tissue between the ages of 17 to 41 years were performed.
RESULTS: In patients with Marfan syndrome and marfan-like states chronic gastritis was an unfavorable factor for the progression of the background atrophic and fibrotic processes in the gastric mucosa. It proved a key role disinhibited to TGFβ activity-dependent activation of fibrogenesis of subepithelial myofibroblasts (α-SMA +) with the development of a special morphogenetic variants of early chronic atrophic multifocal gastritis at a young age.