International journal of molecular sciences · 2021
The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Zarrilli Giovanni, Angerilli Valentina, Businello Gianluca, Sbaraglia Marta, Traverso Giulia, Fortarezza Francesco, Rizzo Stefania, De Gaspari Monica, Basso Cristina, Calabrese Fiorella, Dei Tos Angelo Paolo, Fassan Matteo
Аннотация
A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-related deaths to try and define any possible specific pattern. Histopathologic alterations are principally found within lungs and blood vessels, and these abnormalities also seem to have the highest clinical impact. Nevertheless, many of the morphological data collected so far are non-specific, fickle, and possibly associated with other co-existing factors. The aim of this minireview is to describe the main histopathological features related to COVID-19 and the mechanism known as "cytokine storm".