Journal of aerosol science · 2025
Dynamic of infectious aerosols generated by cough from patients with pulmonary tuberculosis.
СтатьяНазвание и аннотация: Перевод в очереди
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Tristão Taline Canto, Ferreira Mariana Abou Mourad, de Almeida Júnior Pedro Sousa, Castellani Luiz Guilherme Schmidt, Brunetti Manuela Negrelli, Jones-López Edward C, Fennelly Kevin P, Barer Michael R, Fantecelle Carlos Henrique, Morellato Saulo Almeida, Hadad David Jamil, Ellner Jerrold J, Dietze Reynaldo, Palaci Moisés
Аннотация
Tuberculosis (TB) is an ancient disease transmitted through aerosols frequently generated by coughing and it is still unknown whether there is variability in cough aerosol output throughout the day and whether this may impact patients' infectivity categorization. To study the dynamic of infectious aerosols generated by cough, we conducted a cross-sectional study on pulmonary TB patients (n=16) who had their cough-generated aerosols sampled twice daily for two consecutive days for the Cough Aerosol Sampling System (CASS) assay. Most patients were classified as Variable Low Producers and Variable High Producers (n=10; 62.5%), followed by Negative Producers (n = 4; 25%) and Consistent Producers (n = 2; 12.5%). Additionally, most recovered bacilli (88.7 %) within a respiratory aerosol size range. Although the time of collection did not appear to impact on aerosol infectivity, performing CASS with multiple samples allowed for more accurate detection and distinction among aerosol producers.