World journal of urology · 2024
The role of oral antioxidants in the improvement of sperm parameters in infertile men.
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Kallinikas Georgios, Tsoporis James N, Haronis Georgios, Zarkadas Anastasios, Bozios Dimitrios, Konstantinopoulos Vassilios, Kozyrakis Diomidis, Mitiliniou Despoina, Rodinos Evangelos, Filios Athanasios, Filios Panagiotis, Vlassopoulos Gerasimos
Аннотация
PURPOSE: A variety of pathologic conditions may increase oxidative stress in semen resulting in structural modifications to spermozoa's plasma membrane that interfere with sperm motility, morphology, and count. Antioxidants are currently being marketed to treat male infertility. In semen, antioxidants may decrease oxidative stress and potentially improve sperm parameters. In this narrative, mini-review we evaluated the effectiveness of antioxidants in infertility.
METHODS: This mini-review of the current literature has been carried out through searching of the PubMed and Google scholar databases.
RESULTS AND CONCLUSIONS: The literature review suggests that there is evidence that oral antioxidants such as selenium, carnitine, zinc, coenzymeQ10, vitamins E and C, etc. alone or in combinations, improve sperm count, motility, morphology as well as pregnancy rates in infertile men with idiopathic oligoasthenospermia. Unfortunately, most of these studies are poorly designed, limited by sample size, varying in dosage, differing in primary end points, and most notably lacking live birth data. Importantly, large randomized, well-designed, placebo-controlled trials are needed.
METHODS: This mini-review of the current literature has been carried out through searching of the PubMed and Google scholar databases.
RESULTS AND CONCLUSIONS: The literature review suggests that there is evidence that oral antioxidants such as selenium, carnitine, zinc, coenzymeQ10, vitamins E and C, etc. alone or in combinations, improve sperm count, motility, morphology as well as pregnancy rates in infertile men with idiopathic oligoasthenospermia. Unfortunately, most of these studies are poorly designed, limited by sample size, varying in dosage, differing in primary end points, and most notably lacking live birth data. Importantly, large randomized, well-designed, placebo-controlled trials are needed.