Clinical endocrinology · 1994
Inhibin as a marker for hydatidiform mole: a comparative study with the determinations of intact human chorionic gonadotrophin and its free beta-subunit.
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Badonnel Y, Barbé F, Legagneur H, Poncelet E, Schweitzer M
Аннотация
OBJECTIVE: The purpose of the study was to evaluate plasma inhibin as a marker of hydatidiform mole and to compare the results with intact human chorionic gonadotrophin (hCG) and its free beta-subunit.
DESIGN: Serial determinations of the plasma concentrations of inhibin, intact human chorionic gonadotrophin and its free beta-subunit in cases of hydatidiform mole over an average period of 140 days.
PATIENTS: Five cases of hydatidiform mole, including patients with spontaneous remission after evacuation or persistent trophoblastic disease.
MEASUREMENTS: Immunoreactive inhibin, hCG and free hCG beta-subunit were measured using standard enzyme immunoassays.
RESULTS: Inhibin and free hCG beta-subunit levels were greater than in normal pregnant women at the same gestational age. Only intact hCG could detect the persistence of trophoblastic tissue.
CONCLUSIONS: Our data suggest that inhibin, intact human chorionic gonadotrophin and free beta-subunit might be useful as diagnostic markers of molar pregnancies. However, the original method of intact hCG determination is still superior for follow-up.
DESIGN: Serial determinations of the plasma concentrations of inhibin, intact human chorionic gonadotrophin and its free beta-subunit in cases of hydatidiform mole over an average period of 140 days.
PATIENTS: Five cases of hydatidiform mole, including patients with spontaneous remission after evacuation or persistent trophoblastic disease.
MEASUREMENTS: Immunoreactive inhibin, hCG and free hCG beta-subunit were measured using standard enzyme immunoassays.
RESULTS: Inhibin and free hCG beta-subunit levels were greater than in normal pregnant women at the same gestational age. Only intact hCG could detect the persistence of trophoblastic tissue.
CONCLUSIONS: Our data suggest that inhibin, intact human chorionic gonadotrophin and free beta-subunit might be useful as diagnostic markers of molar pregnancies. However, the original method of intact hCG determination is still superior for follow-up.