Academic radiology · 2025
Novel MRI-based Hyper-Fused Radiomics for Predicting Pathologic Complete Response to Neoadjuvant Therapy in Breast Cancer.
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Cui Quan-Xiang, Zhou Liang-Qin, Wang Xin-Yi, Zhang Hong-Xia, Li Jing-Jing, Xiong Ming-Cong, Shi Hai-Yang, Zhu Yue-Min, Sang Xi-Qiao, Kuai Zi-Xiang
Аннотация
RATIONALE AND OBJECTIVES: To propose a novel MRI-based hyper-fused radiomic approach to predict pathologic complete response (pCR) to neoadjuvant therapy (NAT) in breast cancer (BC).
MATERIALS AND METHODS: Pretreatment dynamic contrast-enhanced (DCE) MRI and ultra-multi-b-value (UMB) diffusion-weighted imaging (DWI) data were acquired in BC patients who received NAT followed by surgery at two centers. Hyper-fused radiomic features (RFs) and conventional RFs were extracted from DCE-MRI or UMB-DWI. After feature selection, the following models were built using logistic regression and the retained RFs: hyper-fused model, conventional model, and compound model that integrates the hyper-fused and conventional RFs. The output probability of each model was used to generate a radiomic signature. The model's performance was quantified by the area under the receiver-operating characteristic curve (AUC). Multivariable logistic regression was used to identify variables (clinicopathological variables and the generated radiomic signatures) associated with pCR.
RESULTS: The training/external test set (center 1/2) included 547/295 women. The hyper-fused models (AUCs=0.81-0.85) outperformed (p<0.05) the conventional models (AUCs=0.74-0.80) in predicting pCR. The compound models (AUCs=0.88-0.93) outperformed (p<0.05) the hyper-fused models and conventional models for pCR prediction. The hyper-fused radiomic signatures (odds ratios=5.70-12.98; p<0.05) and compound radiomic signatures (odds ratios=1.57-7.71; p<0.05) were independently associated with pCR. These are true for the training and external test sets.
CONCLUSION: The hyper-fused radiomic approach had significantly better performance for predicting pCR to NAT than the conventional radiomic approach, and the hyper-fused RFs provided incremental discrimination of pCR beyond the conventional RFs. The generated hyper-fused radiomic signatures were independent predictors of pCR.
MATERIALS AND METHODS: Pretreatment dynamic contrast-enhanced (DCE) MRI and ultra-multi-b-value (UMB) diffusion-weighted imaging (DWI) data were acquired in BC patients who received NAT followed by surgery at two centers. Hyper-fused radiomic features (RFs) and conventional RFs were extracted from DCE-MRI or UMB-DWI. After feature selection, the following models were built using logistic regression and the retained RFs: hyper-fused model, conventional model, and compound model that integrates the hyper-fused and conventional RFs. The output probability of each model was used to generate a radiomic signature. The model's performance was quantified by the area under the receiver-operating characteristic curve (AUC). Multivariable logistic regression was used to identify variables (clinicopathological variables and the generated radiomic signatures) associated with pCR.
RESULTS: The training/external test set (center 1/2) included 547/295 women. The hyper-fused models (AUCs=0.81-0.85) outperformed (p<0.05) the conventional models (AUCs=0.74-0.80) in predicting pCR. The compound models (AUCs=0.88-0.93) outperformed (p<0.05) the hyper-fused models and conventional models for pCR prediction. The hyper-fused radiomic signatures (odds ratios=5.70-12.98; p<0.05) and compound radiomic signatures (odds ratios=1.57-7.71; p<0.05) were independently associated with pCR. These are true for the training and external test sets.
CONCLUSION: The hyper-fused radiomic approach had significantly better performance for predicting pCR to NAT than the conventional radiomic approach, and the hyper-fused RFs provided incremental discrimination of pCR beyond the conventional RFs. The generated hyper-fused radiomic signatures were independent predictors of pCR.