Brief Report: Disparities in PrEP Use Among HIV-Negative Black and Latina Women of Transgender Experience and Transfeminine People in Los Angeles County from 2019 to 2020 to 2023-2024.

This study examined PrEP uptake and the role of gender-affirming care among Black and Latina women of transgender experience and transfeminine people (WTE/TFP) in Los Angeles County from 2019 to 2020 and 2023-2024. PrEP use increased substantially among Latinas (28% to 49%) but declined among Black participants (32% to 21%). PrEP uptake was more prevalent among participants using hormones or reporting methamphetamine use. Having trusted gender-affirming providers increased PrEP use more for Black than Latina participants. Our findings highlight the importance of integrating HIV prevention within gender-affirming care and align with calls for community-led approaches, particularly to mobilize Black WTE/TFP and rebuild trust.