Zhongguo yao li xue bao = Acta pharmacologica Sinica · 1997
Sorbitol accumulation in rats kept on diabetic condition for short and prolonged periods.
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Ferraz M, Ishii-Iwamoto E L, Batista M R, Brunaldi K, Bazotte R B
Аннотация
AIM: To study the influence of the course of diabetes, aging, and glycemia on the sorbitol accumulation in diabetic rats.
METHODS: Streptozocin (Str) diabetic rats were obtained by Str i.v. (35 mg.kg-1). Glycemia and sorbitol levels from sciatic nerve and lens were measured after 1 d, 2, 5, and 8 months of diabetes. Sorbitol concentrations in serum, heart, diaphragm, small intestine, and kidney after 8 months of diabetes were measured.
RESULTS: Diabetic rats after Str injection showed hyperglycemia (> 1.7 g.L-1), hyperphagia, polyuria, polydipsia, and loss of body weight. Sorbitol levels in lens and sciatic nerve increased in normal and diabetic rats; the increase was higher in diabetic rats. No relationship was shown between glycemia and sorbitol levels. An increased sorbitol level after 8 months of diabetes was found in small intestine and kidney.
CONCLUSION: The sorbitol levels increased in lens and sciatic nerve with aging and this process was accelerated by diabetes.
METHODS: Streptozocin (Str) diabetic rats were obtained by Str i.v. (35 mg.kg-1). Glycemia and sorbitol levels from sciatic nerve and lens were measured after 1 d, 2, 5, and 8 months of diabetes. Sorbitol concentrations in serum, heart, diaphragm, small intestine, and kidney after 8 months of diabetes were measured.
RESULTS: Diabetic rats after Str injection showed hyperglycemia (> 1.7 g.L-1), hyperphagia, polyuria, polydipsia, and loss of body weight. Sorbitol levels in lens and sciatic nerve increased in normal and diabetic rats; the increase was higher in diabetic rats. No relationship was shown between glycemia and sorbitol levels. An increased sorbitol level after 8 months of diabetes was found in small intestine and kidney.
CONCLUSION: The sorbitol levels increased in lens and sciatic nerve with aging and this process was accelerated by diabetes.