Science (New York, N.Y.) · 2025
Ancient Borrelia genomes document the evolutionary history of louse-borne relapsing fever.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Swali Pooja, Booth Thomas, Tan Cedric C S, McCabe Jesse, Anastasiadou Kyriaki, Barrington Christopher, Borrini Matteo, Bricking Adelle, Buckberry Jo, Büster Lindsey, Carlin Rea, Gilardet Alexandre, Glocke Isabelle, Irish Joel D, Kelly Monica, King Megan, Petchey Fiona, Peto Jessica, Silva Marina, Speidel Leo, Tait Frankie, Teoaca Adelina, Valoriani Satu, Williams Mia, Madgwick Richard, Mullan Graham, Wilson Linda, Cootes Kevin, Armit Ian, Gutierrez Maximiliano G, van Dorp Lucy, Skoglund Pontus
Аннотация
Several bacterial pathogens have transitioned from tick-borne to louse-borne transmission, which often involves genome reduction and increasing virulence. However, the timing of such transitions remains unclear. We sequenced four ancient Borrelia recurrentis genomes, the agent of louse-borne relapsing fever, dating from 2300 to 600 years ago. We estimated the divergence from its closest tick-borne relative to 6000 to 4000 years ago, which suggests an emergence coinciding with human lifestyle changes such as the advent of wool-based textiles. Pan-genome analysis indicated that much of the evolution characteristic of B. recurrentis had occurred by ~2300 years ago, though further gene turnover, particularly in plasmid partitioning, persisted until ~1000 years ago. Our findings provide a direct genomic chronology of the evolution of this specialized vector-borne pathogen.