Fasciculation. Electromyographic and clinical significance.

Fascicular twitching of muscles may be present as the result of compression of spinal roots or anterior horn cells, injuries of peripheral nerves or plexes or to motor neuron disease. Occasionally fasciculation may be of no clinical significance. Electromyography may be of great help in determining the extent of involvement and whether other manifestations of nerve damage are present. Final diagnosis, however, depends upon the history, physical examination and clinical evaluation, since fasciculation is present in a wide variety of conditions.