Actual versus ideal donor body weight in planning bone marrow harvest.

BACKGROUND

Donor selection and harvest volume calculation typically use actual body weight (ABW). However, in obese donors, increased ABW mainly reflects adipose tissue rather than hematopoietic stem cell (HSC)-rich bone marrow. This study aimed to investigate whether ideal body weight (IBW) is a better indicator than ABW for estimating the required HSC yield.

STUDY DESIGN AND

METHODS

This study included 157 donors (106 men and 51 women) with a body mass index of ≥ 22. An analysis of the correlation between harvested HSCs and harvested volume per ABW and IBW was performed. Another analysis of the correlation between the decrease in hemoglobin levels and the harvested volume per ABW or IBW was performed.

RESULTS

No significant differences were observed in the correlations between total nucleated cell counts and the harvested volume per ABW or IBW, between CD34+ HSCs and the harvested volume per ABW or IBW, and between the decrease in hemoglobin levels and the harvested volume per ABW or IBW in all donors and obese donors.

CONCLUSIONS

These results showed no significant differences between IBW and ABW as indicators for estimating the required HSC yield. Additionally, the results showed that harvesting per ABW was not excessive.