Functional blockade of the parabrachial area by tetrodotoxin disrupts the acquisition of conditioned taste aversion induced by motion-sickness in rats.

The role of the parabrachial area in conditioned taste aversion (CTA) induced by motion-sickness was studied in male Wistar rats. In the first experiment, one-trial conditioned taste aversion, to a 0.5% decaffeinated coffee solution, was induced by 30 min of vertical rotatory motion (80 rev./min) in intact rats. In the second experiment, reversible blockade of the neural activity in various brainstem sites was induced by bilateral intracerebral injections of tetrodotoxin (TTX) (10 ng/microl) after conditioning. Blockade of the parabrachial area, but neither A8 nor lateral vestibular nucleus, disrupted the acquisition of (CTA). The results are discussed in terms of an associative role of the parabrachial area in body rotation-induced taste aversion learning, as the area was intact during sensory processing and testing.