Cancer treatment and research communications · 2025
Intercostal nerves cryoanalgesia and open thoracotomy for major lung resection: evaluation of perioperative outcomes and medico-economic analysis.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Stasiak Florent, Pappafava Elena, Jolly Clara, Baillot Sylvain, Streit Arthur, Siat Joëlle, Renaud Stéphane, Seitlinger Joseph
Аннотация
BACKGROUND: Thoracotomy is still required for major lung resections, though minimally invasive approaches are increasing. Postoperative pain and respiratory issues remain challenges, and current analgesia like epidurals have limitations. Intercostal nerves cryoanalgesia has emerged as a promising alternative, but its clinical and economic impact in thoracotomy remains underexplored.
MATERIALS AND METHODS: We conducted a retrospective, observational, single-center study comparing two groups: a standard of care group (SOC, n = 54) and a cryoanalgesia group (CRYO, n = 29). All patients underwent thoracotomy with major lung resection. The CRYO group additionally received intercostal nerves cryoanalgesia. We analyzed postoperative complications, pain levels, ICU and hospital length of stay, morphine consumption, and direct hospitalization costs.
RESULTS: Cryoanalgesia significantly reduced overall postoperative complications (24.1 % vs 50.0 %, p = 0.034), particularly respiratory complications (10.3 % vs 37 %, p = 0.035). ICU stay was shorter in the CRYO group (2 (IQR = 1) vs 3 (IQR = 1) days, p = 0.001), while total hospital stay showed no significant difference. Pain scores and morphine use were similar in both groups. The cost analysis showed lower ICU-related costs in the CRYO group, as well as a financial benefit for the French public health system.
CONCLUSION: Intercostal nerves cryoanalgesia during thoracotomy is associated with reduced postoperative and respiratory complications and a shorter ICU stay, while pain levels remain similar. These benefits may improve patient outcomes and reduce ICU burden, suggesting a medico-economic benefit for cryoanalgesia in thoracic surgery.
MATERIALS AND METHODS: We conducted a retrospective, observational, single-center study comparing two groups: a standard of care group (SOC, n = 54) and a cryoanalgesia group (CRYO, n = 29). All patients underwent thoracotomy with major lung resection. The CRYO group additionally received intercostal nerves cryoanalgesia. We analyzed postoperative complications, pain levels, ICU and hospital length of stay, morphine consumption, and direct hospitalization costs.
RESULTS: Cryoanalgesia significantly reduced overall postoperative complications (24.1 % vs 50.0 %, p = 0.034), particularly respiratory complications (10.3 % vs 37 %, p = 0.035). ICU stay was shorter in the CRYO group (2 (IQR = 1) vs 3 (IQR = 1) days, p = 0.001), while total hospital stay showed no significant difference. Pain scores and morphine use were similar in both groups. The cost analysis showed lower ICU-related costs in the CRYO group, as well as a financial benefit for the French public health system.
CONCLUSION: Intercostal nerves cryoanalgesia during thoracotomy is associated with reduced postoperative and respiratory complications and a shorter ICU stay, while pain levels remain similar. These benefits may improve patient outcomes and reduce ICU burden, suggesting a medico-economic benefit for cryoanalgesia in thoracic surgery.