JMIR research protocols · 2026
Evaluation of a Collaborative Practice Agreement Intervention to Improve Access to HIV Prevention Services in Southeastern US Pharmacies: Protocol for a Hybrid Type 1 Effectiveness-Implementation Study.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Hamilton Chante, Hudson Alexis, Chandra Christina, Zissette Seth, Rothman Rachel, Alohan Daniel I, Klepser Donald G, Quamina Alvan, Woodson R Wayne, Holland David, Crawford Natalie D
Аннотация
BACKGROUND: The United States (US) Southeast experiences a disproportionate burden of HIV, compounded by limited access to pre-exposure prophylaxis (PrEP) services due to systemic barriers, such as stigma, medical mistrust, and restrictive pharmacy policies. Collaborative practice agreements (CPAs) between pharmacists and clinicians represent a promising strategy to improve PrEP accessibility through pharmacy-based services.
OBJECTIVE: The Collaborative Agreement-based PrEP Using Pharmacies (CAP-UP) study aims to evaluate the development, implementation, and effectiveness of a CPA template and training resources to enhance pharmacy-based PrEP initiation and adherence in the Southeastern US.
METHODS: The CAP-UP study uses a hybrid type 1 effectiveness-implementation design guided by integrated implementation science frameworks. It includes three phases: (1) exploration, using online surveys and in-depth interviews to identify barriers and facilitators to CPA implementation; (2) preparation, developing and refining a CPA template and training resources; and (3) implementation, piloting the CPA template in 10 community pharmacies within high-HIV-prevalence neighborhoods.
RESULTS: The CAP-UP study was funded in October 2023 by the National Institutes of Health through the Center for AIDS Research (grant P30-AI050409-25S1) as an Ending the HIV Epidemic supplement. Recruitment launched in November 2023 and is actively ongoing, with 264 pharmacy staff having completed surveys as of January 2026. The study aims to recruit a total of 300 participants for surveys and conduct 68 in-depth interviews by February 2026.
CONCLUSIONS: Expanding HIV prevention services through community pharmacies represents a practical and impactful strategy for addressing inequities in HIV prevention that advances health equity. By leveraging implementation science frameworks, our study explores a novel approach to integrating HIV prevention services in pharmacies located in areas with high HIV prevalence. Findings from this work will contribute to the evidence base needed to optimize pharmacy-based PrEP delivery and support the national goal of Ending the HIV Epidemic in the US.
OBJECTIVE: The Collaborative Agreement-based PrEP Using Pharmacies (CAP-UP) study aims to evaluate the development, implementation, and effectiveness of a CPA template and training resources to enhance pharmacy-based PrEP initiation and adherence in the Southeastern US.
METHODS: The CAP-UP study uses a hybrid type 1 effectiveness-implementation design guided by integrated implementation science frameworks. It includes three phases: (1) exploration, using online surveys and in-depth interviews to identify barriers and facilitators to CPA implementation; (2) preparation, developing and refining a CPA template and training resources; and (3) implementation, piloting the CPA template in 10 community pharmacies within high-HIV-prevalence neighborhoods.
RESULTS: The CAP-UP study was funded in October 2023 by the National Institutes of Health through the Center for AIDS Research (grant P30-AI050409-25S1) as an Ending the HIV Epidemic supplement. Recruitment launched in November 2023 and is actively ongoing, with 264 pharmacy staff having completed surveys as of January 2026. The study aims to recruit a total of 300 participants for surveys and conduct 68 in-depth interviews by February 2026.
CONCLUSIONS: Expanding HIV prevention services through community pharmacies represents a practical and impactful strategy for addressing inequities in HIV prevention that advances health equity. By leveraging implementation science frameworks, our study explores a novel approach to integrating HIV prevention services in pharmacies located in areas with high HIV prevalence. Findings from this work will contribute to the evidence base needed to optimize pharmacy-based PrEP delivery and support the national goal of Ending the HIV Epidemic in the US.