Obstetrics and gynecology · 1993
Immunohistochemical localization of inhibin-activin subunits in hydatidiform mole and invasive mole.
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Minami S, Yamoto M, Nakano R
Аннотация
OBJECTIVE: To examine the cellular localization of each inhibin subunit in hydatidiform mole and invasive mole.
METHODS: Tissues were collected and fixed in Bouin's solution and studied with the immunohistochemical technique avidin-biotin-peroxidase complex.
RESULTS: In the villous trophoblasts of hydatidiform mole and invasive mole, distinct immunostaining for inhibin alpha-subunit was observed in proliferative syncytiotrophoblasts, but not in the cytotrophoblasts. Positive immunostaining for beta A- and beta B-subunits was observed in both syncytiotrophoblasts and cytotrophoblasts. In extravillous trophoblasts of the invasive mole, staining for beta A- and beta B-subunits was observed, whereas staining for alpha-subunit was not detected.
CONCLUSION: Inhibin-activin subunits may be produced in the trophoblasts of hydatidiform mole and invasive mole, and inhibin and activin may play a role in trophoblastic proliferation and invasion.
METHODS: Tissues were collected and fixed in Bouin's solution and studied with the immunohistochemical technique avidin-biotin-peroxidase complex.
RESULTS: In the villous trophoblasts of hydatidiform mole and invasive mole, distinct immunostaining for inhibin alpha-subunit was observed in proliferative syncytiotrophoblasts, but not in the cytotrophoblasts. Positive immunostaining for beta A- and beta B-subunits was observed in both syncytiotrophoblasts and cytotrophoblasts. In extravillous trophoblasts of the invasive mole, staining for beta A- and beta B-subunits was observed, whereas staining for alpha-subunit was not detected.
CONCLUSION: Inhibin-activin subunits may be produced in the trophoblasts of hydatidiform mole and invasive mole, and inhibin and activin may play a role in trophoblastic proliferation and invasion.