Immunity · 2025
Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bündgen Georg, Ulges Alexander, Pietruschka Jan, Truong-Andrievici Natalia, Klein Matthias, Romaniuk Karolina, Schmitt Fabian, Hagen Mathias, Seebass Joachim G, Zezlina Lenart, Stein Lara, Probst Hans Christian, Distler Ute, Tenzer Stefan, Lohoff Michael, Romero-Olmedo Addi J, Mei Henrik, Bohn Toszka, Delacher Michael, Schmidlin Thierry, Gaida Matthias M, Dikic Ivan, Imbusch Charles, Schild Hansjörg, Bopp Tobias
Аннотация
In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that can also influence tissue homeostasis and repair. However, it is not known how these functions are molecularly controlled and whether they are influenced by tumor metabolism. Here, we report that excessive release of polyamines in the tumor microenvironment directs the functional polarization of Treg cells toward immunosuppression in a protein kinase CK2 (CK2)-dependent manner. Polyamine deprivation as well as genetic or pharmacological inhibition of CK2 activity in Treg cells induced tissue reparative properties in Treg cells that orchestrated efficient antitumor type 2 immune responses and coordinated tissue repair mechanisms to support tumor eradication. These findings suggest that targeted modulation of Treg cell functions could be leveraged as a potential avenue for cancer therapy.