Drug design, development and therapy · 2015
Novel synthesizing method of pH-dependent doxorubicin-loaded anti-CD22-labelled drug delivery nanosystem.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sun Mengjiao, Wang Jun, Lu Qin, Xia Guohua, Zhang Yu, Song Lina, Fang Yongjun
Аннотация
The objective of this study was to investigate the anticancer efficacy of dimercaptosuccinic acid-modified iron oxide magnetic nanoparticles coloaded with anti-CD22 antibodies and doxorubicin (anti-CD22-MNPs-DOX) on non-Hodgkin's lymphoma cells. The physical properties of anti-CD22-MNPs-DOX were studied and its antitumor effect on Raji cells in vitro was evaluated using the Cell Counting Kit-8 assay. Furthermore, cell apoptosis and intracellular accumulation of doxorubicin were determined by flow cytometry. The results revealed that anti-CD22-MNPs-DOX inhibited the proliferation of Raji cells, significantly increased the uptake of doxorubicin, and induced apoptosis. Therefore, it was concluded that a coloaded antibody and chemotherapeutic drug with magnetic nanoparticles might be an efficient targeted treatment strategy for non-Hodgkin's lymphoma.
Предметные рубрики MeSH
Antibiotics, AntineoplasticAntibodiesApoptosisBiological TransportCell Line, TumorCell ProliferationChemistry, PharmaceuticalDose-Response Relationship, DrugDoxorubicinDrug CarriersHumansHydrogen-Ion ConcentrationKineticsLymphoma, Non-HodgkinMagnetite NanoparticlesNanotechnologySialic Acid Binding Ig-like Lectin 2SolubilitySuccimerTechnology, Pharmaceutical