Respiratory medicine · 2026
Detection of SARS-CoV-2 in aerosol and surface samples in high acuity hospital settings during community epidemic waves - implications for risk-based infection control.
СтатьяНазвание и аннотация: Перевод в очереди
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MacIntyre C Raina, Notaras Adriana, Bari Noor, Doolan Con, Mahmoud Mohamed Mahmoud Abdelkareem, Honeyman Damian, de Araujo Aquino Andre Fellipe Vilanova, Seppelt Ian, Nicholls Mark, Turville Stuart, Aggarwal Anupriya, Kunasekaran Mohana, Gresham Rebecca, Walker Gregory, Sevendal Andrea, Rawlinson William, Emmen Isla E, O'Connor Shelby L, O'Connor David H, de Silva Charitha
Аннотация
RATIONALE: Nosocomial transmission of SARS-CoV-2 is multifactorial and may vary between clinical sites.
OBJECTIVES: To measure SARS-CoV-2 in the air and on surfaces within the Intensive Care Unit (ICU) and Emergency Department (ED).
METHODS: We conducted an air and surface-sampling study of SARS-CoV-2 in the ED and ICU of a hospital in Sydney.
MEASUREMENTS: We sampled air, patient equipment, and personal protective equipment during two community COVID-19 epidemics. SARS-CoV-2 was detected using quantitative reverse transcription polymerase chain reaction (RT-qPCR). Carbon dioxide (CO2) was measured simultaneously, with <800 ppm indicating good air quality.
MAIN RESULTS: SARS-CoV-2 genetic material was detected in 39% of 51 aerosol samples, with mean CO2 levels consistently <800 ppm for positive samples. The ED had more detections than the ICU (80% vs. 20%; p < 0.0027) and a higher mean CO2 level than the ICU (669 ppm vs. 522 ppm; p < 0.05). The ED waiting room, acute ward, and ICU staff tearoom showed higher detection rates than the ICU ward area. SARS-CoV-2 was detected in air samples in the ED a week before an outbreak was declared, and both inside and outside a COVID-19 patient's negative-pressure ICU room, where high-flow nasal prongs and a glove tested positive.
CONCLUSION: During community epidemics, SARS-CoV-2 genetic material is detected in hospital air despite good ventilation. Enhanced protection with masks, vaccines, and portable air purifiers, especially in high-risk areas, may mitigate nosocomial transmission, including among staff. Air sampling can provide an early warning of an outbreak and help identify areas that need enhanced infection control.
OBJECTIVES: To measure SARS-CoV-2 in the air and on surfaces within the Intensive Care Unit (ICU) and Emergency Department (ED).
METHODS: We conducted an air and surface-sampling study of SARS-CoV-2 in the ED and ICU of a hospital in Sydney.
MEASUREMENTS: We sampled air, patient equipment, and personal protective equipment during two community COVID-19 epidemics. SARS-CoV-2 was detected using quantitative reverse transcription polymerase chain reaction (RT-qPCR). Carbon dioxide (CO2) was measured simultaneously, with <800 ppm indicating good air quality.
MAIN RESULTS: SARS-CoV-2 genetic material was detected in 39% of 51 aerosol samples, with mean CO2 levels consistently <800 ppm for positive samples. The ED had more detections than the ICU (80% vs. 20%; p < 0.0027) and a higher mean CO2 level than the ICU (669 ppm vs. 522 ppm; p < 0.05). The ED waiting room, acute ward, and ICU staff tearoom showed higher detection rates than the ICU ward area. SARS-CoV-2 was detected in air samples in the ED a week before an outbreak was declared, and both inside and outside a COVID-19 patient's negative-pressure ICU room, where high-flow nasal prongs and a glove tested positive.
CONCLUSION: During community epidemics, SARS-CoV-2 genetic material is detected in hospital air despite good ventilation. Enhanced protection with masks, vaccines, and portable air purifiers, especially in high-risk areas, may mitigate nosocomial transmission, including among staff. Air sampling can provide an early warning of an outbreak and help identify areas that need enhanced infection control.