[Simultaneous measurement of end-diastolic pressure in the left ventricle and transmitral flow before and after nitroglycerin in patients with angina pectoris].

In angina pectoris, left ventricular diastolic function evaluated by end-diastolic pressure (LVEDP) on catheterization and transmitral flow (TMF) on Doppler echocardiography is abnormal. As a parameter describing TMF, the ratio between peak flow velocities of the two filling phases in diastole (PE/PA) can be used. We examined 22 patients with angina pectoris and measured LVEDP and PE/PA simultaneously and found positive correlation (r = 0.60). Nitroglycerin (0.8 mg sublingually) reduced LVEDP and PE/PA significantly, and correlation between reductions was positive (r = 0.52). None of the correlation analyses permitted LVEDP to be calculated from PE/PA, but Doppler echocardiography and TMF will probably be used increasingly in evaluation of ischemic heart disease with medical intervention.