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Войти в исследования F&S science · 2020
Aberrant expression of oxytocin receptor in endometrium and decidua in women who have experienced recurrent implantation failure.
СтатьяНазвание и аннотация: Перевод в очереди
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Liu Chang, Li Yuehan, Li Linshuang, Shui Shike, Yang Le, Sui Cong, Zhang Hanwang
Аннотация
OBJECTIVE: To detect the oxytocin receptor (OTR) expression levels in the endometrium and decidua from women who have experienced recurrent implantation failure (RIF) and fertile women.
DESIGN: Laboratory study using human endometrial and decidual samples.
SETTINGS: University-affiliated hospital.
PATIENT(S): Six patients with RIF and six fertile women were recruited for endometrial sampling on day 20-24 of the menstrual cycle. Decidual tissues were collected from women who had a history of RIF and experienced a spontaneous abortion at 6-8 weeks of gestation (n = 8) and women with healthy pregnancies that terminated for nonmedical reasons (n = 8).
INTERVENTION: None.
MAIN OUTCOME MEASURE(S): OTR expression in the endometrial and decidual tissues was detected with the use of real-time quantitative polymerase chain reaction and Western blotting.
RESULT(S): OTR protein and mRNA were significantly increased in the endometria of RIF patients. In the decidua, OTR protein was significantly up-regulated in the RIF group, whereas mRNA was significantly decreased in this group.
CONCLUSION(S): Women who experienced RIF presented with an aberrant expression pattern of OTR in the endometria and decidua.
DESIGN: Laboratory study using human endometrial and decidual samples.
SETTINGS: University-affiliated hospital.
PATIENT(S): Six patients with RIF and six fertile women were recruited for endometrial sampling on day 20-24 of the menstrual cycle. Decidual tissues were collected from women who had a history of RIF and experienced a spontaneous abortion at 6-8 weeks of gestation (n = 8) and women with healthy pregnancies that terminated for nonmedical reasons (n = 8).
INTERVENTION: None.
MAIN OUTCOME MEASURE(S): OTR expression in the endometrial and decidual tissues was detected with the use of real-time quantitative polymerase chain reaction and Western blotting.
RESULT(S): OTR protein and mRNA were significantly increased in the endometria of RIF patients. In the decidua, OTR protein was significantly up-regulated in the RIF group, whereas mRNA was significantly decreased in this group.
CONCLUSION(S): Women who experienced RIF presented with an aberrant expression pattern of OTR in the endometria and decidua.