Antisperm antibody and Klinefelter syndrome: does autoimmunity play a role in the pathogenesis?

Serum samples from 18 patients with Klinefelter syndrome (age range 20-22 years) and from a control group of 18 age-matched healthy subjects were analyzed for antisperm antibodies by a noncompetitive enzyme-linked immunosorbent assay. The antisperm antibody values were found higher in 5 patients (27.7%) than the level of 150 mU/100 microliters which was considered the upper level of the normal range (p < 0.01).