Virology · 2024
Rapid test for hepatitis B core-related antigen to identify people living with hepatitis B having high viral load in Cameroon.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Njouom Richard, Ndiaye Alassane, Modiyinji Abdou Fatawou, Lissock Frederic, Vincent Jeanne Perpétue, Baba Masaya, Yamamoto Naoki, Kaneko Atsushi, Aoyagi Katsumi, Hashimoto Naofumi, Nagai Mari, Ichikawa Masato, Miura Tetsuo, Sugiura Wataru, Tanaka Yasuhito, Shimakawa Yusuke
Аннотация
This study presents a retrospective assessment of the diagnostic performance of the newly developed hepatitis B core-related antigen rapid diagnostic test (HBcrAg-RDT) in detecting plasma samples with elevated hepatitis B virus (HBV) DNA levels (≥200,000 IU/ml) in Yaoundé, Cameroon. Samples were collected consecutively from treatment-naïve adults living with HBV between January 1, 2021, and June 30, 2023. Analyzing 146 samples from participants with a median age of 36 years, the HBcrAg-RDT exhibited a sensitivity of 97.5% (95% CI: 86.8-99.9) and a specificity of 77.4% (68.2-84.9) when compared to real-time PCR as the reference standard. These findings suggest that HBcrAg-RDT holds promise as a valuable point-of-care tool for diagnosing high HBV DNA levels, particularly in resource-limited settings. Further research will refine its practicality and effectiveness.