Nanomedicine (London, England) · 2025
From conventional therapy to novel nano-based approaches. A focus on prostate cancer.
СтатьяОбзорПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Chiaverini Lorenzo, Ferraro Giarita, Di Leo Riccardo, Barresi Elisabetta, La Mendola Diego, Bartoli Francesco, Famlonga Luca, Satriano Cristina, Faviana Pinuccia, Zucchi Alessandro, Pacini Matteo, Gailer Jürgen, Giacomelli Chiara, Marzo Tiziano
Аннотация
The currently available clinical anticancer approaches pertaining to the treatment of prostate cancer are summarized here. After providing an overview of the main features of this highly impactful global disease, the currently available clinical treatments are briefly reviewed. Then, alternative and innovative nano-based therapeutic options that have been proposed or are currently being explored to significantly improve prostate cancer management (i.e. anti-prostate cancer polymeric nanoparticles loaded with drugs to promote their release and biological activity, including non-targeted and functionalized PLGA-PEG NPs and AuNPs), are introduced. Furthermore, the problem of gathering insights into the mechanistic aspects related to the fate of the nanoformulation in complex matrices, such as blood plasma, is addressed.