Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2010
Polymorphisms in DNA damage response genes and head and neck cancer risk.
СтатьяМетаанализПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАОбзорНазвание и аннотация: Перевод в очереди
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Flores-Obando Rafael E, Gollin Susanne M, Ragin Camille C
Аннотация
BACKGROUND: Polymorphisms in DNA repair genes have been reported contributing factors in head and neck cancer risk but studies have shown conflicting results.
OBJECTIVE: To clarify the impact of DNA repair gene polymorphisms in head and neck cancer risk.
METHOD: A meta-analysis including 30 case-control studies was performed.
RESULTS: Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer.
CONCLUSION: Assessments of the effects of smoking, alcohol, human papillomavirus and race/ethnicity on the association between DNA repair gene polymorphisms and head and neck cancer are needed.
OBJECTIVE: To clarify the impact of DNA repair gene polymorphisms in head and neck cancer risk.
METHOD: A meta-analysis including 30 case-control studies was performed.
RESULTS: Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer.
CONCLUSION: Assessments of the effects of smoking, alcohol, human papillomavirus and race/ethnicity on the association between DNA repair gene polymorphisms and head and neck cancer are needed.