Journal of acquired immune deficiency syndromes (1999) · 2026
Brief Report: Clinical Features of Newly Diagnosed Cytomegalovirus Retinitis in South India.
СтатьяНазвание и аннотация: Перевод в очереди
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Rathinam Sivakumar R, Narang Pranay, Somanath Rao Anjana S, Rajendran Anand, Lalitha Prajna, Shen-Sampas John H, Maningding Ernest, Menda Shivali, O'Brien Kieran S, Wittberg Dionna M, Lietman Thomas M, Margolis Todd P, Keenan Jeremy D
Аннотация
BACKGROUND: The clinical features of cytomegalovirus (CMV) retinitis have not been well characterized in India, despite the likely high burden of disease.
SETTING: Tertiary eye hospital in Madurai, India.
METHODS: All patients with a diagnosis of CMV retinitis seen at a single eye hospital from 2007 to 2023 were identified from uvea, retina, and microbiology registries and the hospital administrative database. A standardized chart review was performed.
RESULTS: Among 343 patients diagnosed with CMV retinitis, 322 (94%) were HIV positive. Of 213 patients with a documented date of HIV diagnosis, 54 (25%) were unaware of their HIV status until after being diagnosed with CMV retinitis. Of the 159 HIV-positive patients aware of their diagnosis, 33 (21%) were not yet taking antiretroviral therapy at the time of retinitis diagnosis. At the time of CMV retinitis diagnosis, a total of 52 (16%) patients were bilaterally blind and 57 (18%) had retinal detachment in 1 or both eyes. The number of patients presenting with CMV retinitis each year did not change substantially between 2007 and 2023.
CONCLUSIONS: Patients diagnosed with CMV retinitis at an eye hospital in south India presented with advanced disease, and were frequently unaware of their HIV diagnosis.
SETTING: Tertiary eye hospital in Madurai, India.
METHODS: All patients with a diagnosis of CMV retinitis seen at a single eye hospital from 2007 to 2023 were identified from uvea, retina, and microbiology registries and the hospital administrative database. A standardized chart review was performed.
RESULTS: Among 343 patients diagnosed with CMV retinitis, 322 (94%) were HIV positive. Of 213 patients with a documented date of HIV diagnosis, 54 (25%) were unaware of their HIV status until after being diagnosed with CMV retinitis. Of the 159 HIV-positive patients aware of their diagnosis, 33 (21%) were not yet taking antiretroviral therapy at the time of retinitis diagnosis. At the time of CMV retinitis diagnosis, a total of 52 (16%) patients were bilaterally blind and 57 (18%) had retinal detachment in 1 or both eyes. The number of patients presenting with CMV retinitis each year did not change substantially between 2007 and 2023.
CONCLUSIONS: Patients diagnosed with CMV retinitis at an eye hospital in south India presented with advanced disease, and were frequently unaware of their HIV diagnosis.