[Cerebral hemorrhage associated with the use of phenylpropanolamine. Clinical cases].

We report three women aged 33, 63 and 43 years old receiving an anorexigenic medication that contained phenylpropanolamine who, 30 min to 3 h after the ingestion of this medication, presented a frontal hematoma, a left putaminal hematoma and a subaracnoidal hemorrhage, respectively. Cerebral angiography, performed in all of them, did not show any vascular abnormality. This complication of phenylpropanolamine use, has been reported previously abroad and the mechanism of production, could be related to an elevation of blood pressure and the production of a vasculitis by the drug. The risk of this complication must be taken into account when prescribing phenylpropanolamine.