Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit · 2007
Plasma met-enkephalin, beta-endorphin and leu-enkephalin levels in human hepatic encephalopathy.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Kamel L, Saleh A, Morsy A, Ghali A, El Khayat H
Аннотация
To address the role of the opioid system in the pathogenesis of hepatic encephalopathy (HE) we measured plasma met-enkephalin, beta-endorphin and leu-enkephalin in patients with different grades of HE compared to control subjects and patients with cirrhosis. Plasma met-enkephalin levels were significantly higher in patients with cirrhosis and all grades of HE than controls. Plasma beta-endorphin levels were similar in the 3 groups. Plasma leu-enkephalin levels were significantly higher in HE grades II, III and IV than in controls, patients with cirrhosis and HE grade I patients. Our results support data on the involvement of met-enkephalin and leu-enkephalin in the pathogenesis of HE and provide a rationale for the use of opioid receptor antagonists in the treatment of HE.
Предметные рубрики MeSH
AmmoniaAnalysis of VarianceCase-Control StudiesCausalityEgyptEnkephalin, LeucineEnkephalin, MethionineHepatic EncephalopathyHepatitis BHepatitis CHepatitis, AutoimmuneHumansLiver CirrhosisMetabolic Clearance RateNaltrexoneNarcotic AntagonistsNeurotransmitter AgentsRadioimmunoassaySeverity of Illness IndexStatistics, Nonparametricbeta-Endorphin